首都医学科学创新中心梁银文实验室招聘助理研究员|博士后|科研助理

首都医学科学创新中心梁银文实验室2025年招聘助理研究员、博士后、科研助理

共计 3 个岗位，招 若干 人

发布时间：2025-12-04 | 截止时间：详见正文 | 北京

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首都医学科学创新中心梁银文实验室2025年招聘助理研究员、博士后、科研助理

招若干人，共计3个岗位

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中心简介

首都医学科学创新中心[Chinese Institutes for Medical Research (CIMR), Beijing]（简称创新中心）是北京市新成立的具有独立法人资格的新型研发机构。创新中心以推动医学科学发展、改善人类健康为目标，开展生物医学研究，致力于提升医学科学创新与成果转化能力，提高疾病诊断和治疗水平。我们将汇聚世界高水平科学家，与首都医学教育和科学研究优质资源紧密合作，打造多学科交叉融合的科研平台，综合自由探索、医学目标导向、有组织科研等途径，实践新型科研模式和体制机制，培养适应医学科学创新发展的优秀人才，逐步推进医教研产的深度融合，助力首都医科大学成为世界一流的医科大学。了解更多：ww***.cn[点击查看]

实验室介绍

梁银文博士在厦门大学、清华大学大学生命科学学院分别取得学士、博士学位，加入美国纽约纪念斯隆凯特琳癌症中心（Memorial Sloan Kettering Cancer Center）任博士后、资深科学家（相当于助理研究员），将于2026年1月入职首都医学科学中心的医学生理学研究所担任独立PI，研究员。实验室研究聚焦于胚胎发育和组织稳态的机制，主要研究方向是纤毛发生与其介导的Hedgehog信号通路，采用小鼠、人类遗传学结合多组学工具进行系统研究。以一作含共同通讯作者在Science、Developmental Cell、Current Biology、Journal of Cell Biology等刊物发表多篇高水平论文，报道原创性工作。

本实验室为不同学术背景的研究者提供开放的平台，诚邀有志之士与我们共赴探索、创新之旅。

主要研究方向

1. 鉴定（纤毛）基因调控网络调控的新机制；

2. 解析细胞类型特异性纤毛形成和纤毛形态多样性的机制；

3. 研究纤毛病和SHH髓母细胞瘤的分子机制与治疗方案。

主要研究成果

1. 发现原生纤毛形成的转录调控 总开关

实验室发现了SP5和SP8作为纤毛形成的关键转录调控因子，首次证明了SP5和SP8直接结合并激活多个纤毛基因的表达，包括Foxj1和RFX家族转录因子。由SP5和SP8介导的转录调控网络是纤毛形成所必需的，并且SP8异位表达足以驱动纤毛的形成（Science，2025）。

2. 阐明马达蛋白磷酸化调控机制，提出纤毛长度调控模型

利用莱茵衣藻和小鼠模型，实验室的研究揭示了纤毛装配和内鞭毛运输（IFT）的分子机制，包括通过磷酸化KIF3B的S663位点对其的调控（Developmental Cell, 2014a; Developmental Cell, 2014b）。实验室还提出了通过IFT负载速率控制纤毛长度的模型（Current Biology, 2018）。

3. 揭示纤毛病和SHH髓母细胞瘤的分子机制 (Science, 2025; eLife, 2025; Journal of Cell Biology, 2018; American Journal of Human Genetics, 2018)

代表性文章

Liang Y#, Koche R, Chalamalasetty RB, Stephen DN, Kennedy MW, Lao Z, Pang Y, Kuo YY, Lee M, Lobo FP, Huang X, Hadjantonakis AK, Yamaguchi TP, Anderson KV, Joyner AL#. Transcription factors SP5 and SP8 drive primary cilia formation in mammalian embryos. Science, 2025, 389 (6763): eadt5663. DOI: 10.1126/science. adt5663

Lao Z, Nagar SE, Liang Y, Stephen DN, Joyner AL. PTEN restrains SHH medulloblastma growth through cell autonomous and nonautonomous mechanisms. eLife, 2025. DOI: 10.7554/eLife.108190.1

Liang Y, Zhu X, Wu Q, Pan J. Ciliary Length Sensing Regulates IFT Entry via Changes in FLA8/KIF3B Phosphorylation to Control Ciliary Assembly. Current Biology, 2018, 28(15): 2429-2435.e3. DOI: 10.1016/j.cub.2018.05.069

Agbu SO*, Liang Y*, Liu A, Anderson KV. The small GTPase RSG1 controls a final step in primary cilia initiation. Journal of Cell Biology, 2018, 217(1): 413-427. DOI: 10.1083/jcb.201604048

Liang Y*, Pang Y*, Wu Q, Hu Z, Han X, Xu Y, Deng H, Pan J. FLA8/KIF3B phosphorylation regulates kinesin-II interaction with IFT-B to control IFT entry and turnaround. DevelopmentalCell, 2014, 30(5): 585-97. DOI: 10.1016/j.devcel.2014.07.019 (Highlighted by Craige B and Witman G. Flipping a Phosphate Switch on Kinesin-II to Turn IFT Around. Developmental Cell, 2014, DOI: 10.1016/j.devcel.2014.08.019)



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助理研究员（1-2名）

一、主要职责

1. 在PI指导下独立开展研究工作；

2. 协助PI指导研究生，撰写研究论文和项目申请。

二、任职要求

1. 具有细胞生物学、发育生物学、分子生物学、神经生物学、生物信息学或其他相关领域的研究背景，3年或以上博后经历；

2. 近期以第一作者身份在领域内主流期刊上发表过研究论文；

3. 具备独立开展科研工作和指导研究生能力；

4. 具有高涨的科研热情、严谨的科研态度、良好的沟通能力和团队合作精神；

5. 具备良好的英语读写和交流能力，能够使用英文撰写论文。

博士后（2名）

一、主要职责

1. 在PI指导下独立开展研究工作；

2. 协助指导研究生以及撰写论文和基金申请。

二、任职要求

1. 已获得或即将获得博士学位，具有细胞、发育生物学、生物信息学或其他相关领域的研究背景；

2. 以第一作者身份在领域内主流期刊上发表过或即将发表研究论文；

3. 具备独立开展科研工作能力；

4. 具有高涨的科研热情、严谨的科研态度、良好的沟通能力和团队合作精神；

5. 具备良好的英语读写和日常交流能力，能够使用英文撰写论文。

科研助理（1-2名）

一、主要职责

1. 独立或协助团队开展课题研究；

2. 协助实验室运行管理。

二、任职要求

1. 大学本科学历及以上，分子生物学、细胞生物学、发育生物学、生物化学或其它相关专业；

2. 掌握分子生物学基本原理及操作能力，有细胞生物学、小鼠模型等研究经历优先；

3. 诚实严谨，具备良好的沟通能力和团队协作能力；

4. 具备良好的英语读写和日常交流能力。

福利待遇

1. 根据应聘者的工作经验和能力，提供具有市场竞争力的薪酬（详情面谈）；

2. 享受五险一金、带薪年假、体检和补充医疗保险等；

3. 支持个人职业发展，提供必要的工作相关专业培训。

申请方法

请将简历(含联系方式)、研究兴趣或计划、2-3名推荐人的姓名和联系方式以及其他证明研究能力的材料合并为1个PDF文件发送至liangyinwen@，并在邮件主题中注明申请人的姓名和具体职位。【快捷投递：点击下方 立即投递/投递简历 ，即刻进行职位报名】

联系人：梁银文博士，研究员

联系地址：北京市丰台区右安门外西头条10号-首都医学科学创新中心

本招聘长期有效，至招聘到合适人选为止。

ABOUT CIMR

Chinese Institutes for Medical Research (CIMR) is a newly founded institution dedicated to fundamental and translational medical research. CIMR is located at the main campus of the Capital Medical University, Beijing, China and committed to building a scientist-centered governance framework and fostering a diverse and inclusive work environment. For more information, please visit our website: ww***.cn[点击查看]

Laboratory Introduction

Dr. Yinwen Liang obtained the bachelor s degree from Xiamen University and Ph.D. Degree from Tsinghua University, followed up by postdoc training at Memorial Sloan Kettering Cancer Center, New York, USA. Prior to Joining CIMR, Dr. Liang has been promoted to senior scientist at MSKCC. Dr. Liang will become an independent Principal Investigator (PI) at CIMR in January 2026. The Liang lab at CIMR investigates the fundamental questions of embryonic development and tissue homeostasis, with emphasis on the molecular mechanisms of cilia biology and Hedgehog signaling pathway. The long-term goal is to translate mechanistic insights into therapeutic strategy for ciliopathies and HH driven brain tumor such as medulloblastoma. The team will integrate cutting edge animal models, human genetics and multi-omics approaches to drive these studies.

Major Research Projects

a. Identifying novel regulators of the ciliary gene regulatory network.

b. Dissecting cell-type-specific cilia formation and morphological diversity.

c. Revealing the molecular mechanisms of ciliopathies and SHH-medulloblastoma.

Major Contributions

a. Discovered transcription factors SP5 and SP8 as key transcriptional regulators in cilia formation (Science, 2025).

b. Uncovered the mechanisms of intraflagellar transport machinery and cilia assembly (Current Biology, 2018; Developmental Cell, 2014a; Developmental Cell, 2014b).

c. Revealed molecular insights into ciliopathies and SHH-medulloblastoma (Science, 2025; eLife, 2025; Journal of Cell Biology, 2018; American Journal of Human Genetics, 2018).

Representative Publications

Liang Y#, Koche R, Chalamalasetty RB, Stephen DN, Kennedy MW, Lao Z, Pang Y, Kuo YY, Lee M, Lobo FP, Huang X, Hadjantonakis AK, Yamaguchi TP, Anderson KV, Joyner AL#. Transcription factors SP5 and SP8 drive primary cilia formation in mammalian embryos. Science, 2025, 389 (6763): eadt5663. DOI: 10.1126/science. adt5663

Lao Z, Nagar SE, Liang Y, Stephen DN, Joyner AL. PTEN restrains SHH medulloblastma growth through cell autonomous and nonautonomous mechanisms. eLife, 2025. DOI: 10.7554/eLife.108190.1

Liang Y, Zhu X, Wu Q, Pan J. Ciliary Length Sensing Regulates IFT Entry via Changes in FLA8/KIF3B Phosphorylation to Control Ciliary Assembly. Current Biology, 2018, 28(15): 2429-2435.e3. DOI: 10.1016/j.cub.2018.05.069

Agbu SO*, Liang Y*, Liu A, Anderson KV. The small GTPase RSG1 controls a final step in primary cilia initiation. Journal of Cell Biology, 2018, 217(1): 413-427. DOI: 10.1083/jcb.201604048

Liang Y*, Pang Y*, Wu Q, Hu Z, Han X, Xu Y, Deng H, Pan J. FLA8/KIF3B phosphorylation regulates kinesin-II interaction with IFT-B to control IFT entry and turnaround. DevelopmentalCell, 2014, 30(5): 585-97. DOI: 10.1016/j.devcel.2014.07.019 (Highlighted by Craige B and Witman G. Flipping a Phosphate Switch on Kinesin-II to Turn IFT Around. Developmental Cell, 2014, DOI: 10.1016/j.devcel.2014.08.019)



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Open Positions

Research Assistant Investigator

Main Responsibilities

a. Conduct research independently under the guidance of the PI.

b. Assist in supervising graduate students and in writing research papers and grant proposals.

Qualifications

a. A Ph.D. in cell biology, developmental biology, neurology, bioinformatics or related fields, with at least 3 years of postdoctoral research experience.

b. A strong publication record, evidenced by first-author publications in reputable journals.

c. Demonstrated ability to conduct independent research and mentor graduate students, with a strong passion for scientific research.

d. High proficiency in written and spoken English, with the ability to communicate effectively and prepare manuscripts.

Postdoctoral Researcher

Main Responsibilities

a. Conduct research projects independently under the guidance of the PI.

b. Assist in supervising graduate students and writing research papers and grant proposals.

Qualifications

a. A recent Ph.D. in cell biology, molecular biology, developmental biology, bioinformatics or related fields.

b. Proven track record of first-author publications in reputable journals in the field.

c. Demonstrated ability to conduct independent research and mentor graduate students, with a strong passion for scientific research.

d. Proficiency in written and spoken English, with the ability to communicate effectively and prepare manuscripts.

Research Assistant

Main Responsibilities

a. Assist the team in conducting research projects.

b. Oversee the daily operation and maintenance of laboratory equipment, and assist the PI with lab management and administrative tasks.

Qualifications

a. Bachelor's degree or higher in molecular biology, cell biology, developmental biology, biochemistry or related fields.

b. Proactive work attitude with strong organizational skills and attention to detail.

c. Excellent communication skills and a collaborative team spirit.

d. Proficiency in English reading, writing, and daily communication.

Welfare Treatment

a. Competitive salary based on the applicant s work experience and ability (salary negotiable).

b. Social insurance and housing fund, supplementary medical insurance, physical examination and paid annual leave.

c. Opportunities for career development and available professional guidance.

How to apply

Please email the following documents to a single PDF to: liangyinwen@, and indicate the applicant's name and specific job position in the email subject.

a. Updated CV with contact information.

b. Short summary of research experience and interests.

c. Names and contact details of two or three references.

Contact person: Dr. Yinwen Liang

This recruitment is valid for the long term until a suitable candidate is recruited.

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